Molecular Nano Dynamics/Single Bio Cells

Project Team

Research Activities

Link

A01 Reaction Measurement in Single Bio Cells A02 A03 A04

We will develop new methodologies to create reaction fields in living cells by introducing probe molecules and nanoparticles to the single cells and microspectroscopic methods whose spatial resolution is smaller than light wavelength.

◆ Theme

(1) Creation chemical reaction fields in single bio cell which can be spectoscopically measured.

(2) Development of super-resolution microscopy whose resolution overcomes diffraction limit of light.

◆ Keywords

single bio cell, time-resolved imaging,time- and space-resolved spectroscopy

◆ Research Area

photochemistry, scientific instrumentation, Bio cell chemistry, laser process

Topics

detail

Structural change dynamics of
single bio-cell induced by laser excitation

◆ Planned Subjects

Creation of Reaction Fields in Single Bio Cells and Measurement of Their Reaction: Hiroshi MASUHARA (Professor, Osaka Univ.)
Development of Picosecond IR Super-Resolution Microscopy and Its Application to Cell: Masaaki FUJII (Professor, Tokyo Inst. Tech.)
Study on Adaptation of Single Photosynthetic Cells against Enviromental Stress by Using Three-Dimensional Super-Resolution Microscopy with Time-Resolution Ability: Shigeichi Kumazaki (Associate Professor, Kyoto Univ.)
Photothermal and Photoionization Spectroscopies of Chemical Reactions in a Single Cell: Akira Harata (Professor, Kyushu Univ.)
Stark Spectroscopy and Reaction Dynamics in a Single Cell: Nobuhiro Ohta (Professor, Hokkaido Univ.)

◆ Proposed Research Subjects

Dynamic Cell Analysis Using Photon Force Spectroscopy: Keiji SASAKI （Professor, Hokkaido University）
Dynamics Control of Reaction in Single Cells by Photo-Labeled Globular Macromolecules: Keigo AOI （Professor, Nagoya University）
Fluorescence Dynamics in Single Cells Using Quantum Dot, Organic, and Biorelevant Probes: Yasuhiro AOYAMA （Professor, Kyoto University）
Dynamic Analysis of Plant Defence Responses Based on Single Cell Metabolite Mapping: Akio KOBAYASHI （Professor, Osaka University）
Dynamics of Macromolecular Carriers with Drugs and Genes in a Single Cell: Akira HARADA （Professor, Osaka University）
Matrix Spectroscopy for Noninvasive Evaluation of Cell Differentiation: Yasuo KANEMATSU （Professor, Osaka University）
Nonlinear Vibrational Nanospectroscopy: Yasushi INOUYE （Professor, Osaka University）
Differentiation Dynamics of Single Embryonic Stem Cell Suspended with Optical Tweezer: Masahiro KISHIDA （Professor, Kyushu University）
Photochemical Reactions in Single Bio Cell Triggered by Photothermal Reshaping of Gold Nanorods: Yasuro NIIDOME （Associate Professor, Kyushu University）
Laser Induced Injection of Gold Nanoparticles into Chloroplasts and Plasmon Enhanced Photosynthesis: Akito ISHIDA （Associate Professor, Kyoto Prefectural University）
Design of Fluorescent Base for Gene Diagnosis in Cell: Isao SAITO （Professor, Nihon University）
Fluorescence Correlation Spectroscopy for The Measurement of Time- and Space-Dependence of Transport Phenomena and Its Application to Cell Systems: Kiminori USHIDA （Unit Leader, RIKEN）

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